Heart failure, a condition in which the heart cannot pump enough blood to serve the body’s normal requirements, can cause significant problems for patients’ quality of life. In a majority of patients with heart failure, one chamber of the heart, the left ventricle, does not pump out, or “eject,” as much blood as a healthy heart. However, in many heart failure patients, the left ventricle ejects the normal amount of blood, a condition known as “heart failure with a normal ejection fraction.” Patients with heart failure are also commonly found to suffer from coronary atherosclerosis, the unhealthy thickening of the walls of the arteries around the heart. This study investigates the possibility that the health outcomes for many patients suffering from heart failure with a normal ejection fraction actually result largely from their coronary atherosclerosis. If this is confirmed, it would have significant implications for the medical care for these patients. The principal investigator at Weill Cornell Cardiology is Dr. Fay Lin. This work is funded by a grant from the American Heart Association. The study is currently open to enrollment: see studies open to enrollment.