Cardiology

You are here

Studies Open to Enrollment

Arrythmia and Cardiac Electrophysiology

This research study is for men and women who are diagnosed with ventricular tachycardia suitable for ablation. The purpose of the study is to assess the utility of an imaging procedure known as contrast-enhanced intracardiac echocardiography (ICE) in this procedure.

Study subjects are enrolled for one or two days only.

Read More

Interventional Cardiology and Valvular Heart Disease

This clinical trial is for men and women diagnosed with ischemic heart disease (myocardial ischemia) who are eligible to be treated with coronary angioplasty (PCI). Eligible patients include persons with angina (stable, unstable, or post-infarct), or silent ischemia.

The purpose of the study is to evaluate the safety and effectiveness of the Absorb Bioresorbable Vascular Scaffold (BVS) System made by Abbott Vascular. Unlike traditional metal stents which remain in the body permanently, the Absorb BVS dissolves into the blood vessel, leaving behind a treated vessel that is free of a permanent metallic implant.

Study subjects will be randomized to receive either the Absorb BVS or a commercially approved stent, and will be followed up for 5 years.

Read More

This clinical trial is for men and women who are diagnosed with mitral regurgitation (MR), mitral insufficiency or mitral incompetence and are at extremely high risk for open mitral valve surgery.

The purpose of the study is to assess the safety and effectiveness of the MitraClip device, the first device for repair of the mitral valve that is delivered by a catheter, avoiding the need for heart surgery.  Half of the eligible study subjects will be randomized to undergo the MitraClip procedure, and the other half will continue to be treated according to standard medical care without the MitraClip procedure.

Study subjects will be followed up for 5 years after placement of the stent.

Read More

Enrollment in this trial is temporarily on hold.

This clinical trial is for men and women who are diagnosed with ischemic or congestive heart failure (CHF) after a myocardial infarction (MI or “heart attack”).  

The purpose of the study is to assess the efficacy and long-term safety of the CardioKinetix Parachute device, an umbrella-shaped membrane that is is implanted inside the left ventricle of the heart. This creates a partition in the ventricle, reducing the effective size of the chamber and restoring its natural shape somewhat, which has been shown to be important for the treatment of heart failure. It is implanted with a catheter procedure, avoiding the risks of surgery.

Study subjects will be followed up for 5 years after placement of the stent.

Read More

This clinical trial is for men and women who are diagnosed with severe aortic stenosis and are at intermediate-risk for traditional open-heart surgery for aortic valve replacement.

The purpose of the study is to assess the safety and effectiveness of the SAPIEN XT and SAPIEN 3 transcatheter heart valves. Unlike traditional replacement aortic valves, they are implanted with a catheter procedure to eliminate the need for surgery.  These devices are approved by FDA for patients who are at high-risk for traditional open-heart surgery.

Study subjects will be followed up for 5 years after placement of the stent.

Read More

This clinical trial is for men and women diagnosed with an atrial septal defect, which is an opening between the right and left upper chambers of the heart. As part of this study, the doctor will attempt to implant the AMPLATZER™ Septal Occluder (ASO) to close this hole. The ASO is approved by the FDA to close atrial septal defects. The device, procedures and tests used in this study are not considered experimental.

The purpose of the study is to gather more information about the possible risk factors associated with the occurrence of a rare type of negative effect, called erosion, and the presence of the implanted ASO device.

Study subjects will be followed up for 12 months after the placement of the ASO.

Read More

This clinical trial is for men and women diagnosed with coronary artery disease who qualify for stenting of coronary artery lesions.  

The purpose of the study is to evaluate the safety and efficacy of the Orsiro Sirolimus Eluting Coronary Stent System made by Biotronik. This is a thin, flexible stent that is coated with a material that inhibits inflammation and cell proliferation, which may reduce adverse reactions compared to other metal stents.

Study subjects will be followed up for up to 5 years after placement of the stent.

Read More

This clinical trial is for men and women diagnosed with clinically significant functional mitral regurgitation who are determined to have an unacceptably high risk from surgery.  

The purpose of the study is to evaluate the safety and effectiveness of the MitraClip System made by Abbott Vascular, Inc. The MitraClip System is the first FDA-approved mitral valve repair therapy that is percutaneous, meaning that access to the heart is gained by means of a catheter, as with angioplasty or stenting, rather than by an open heart surgery. This provides a treatment option for select patients with mitral regurgitation.

Study subjects will be randomized in a 1:1 ratio either to receive the MitraClip device, or to be treated without the device by standard medical care. Study subjects are followed up for 5 years.

Read More

This clinical trial is for men and women who will be treated with peripheral endovascular interventions (PEI).

The purpose of the study is to determine whether anticoagulation treatment with a drug called bivalirudin (manufactured by The Medicines Company under the trade name Angiomax®) results in fewer major bleeding complications compared with heparin in subjects undergoing PEI. Bivalrudin is an anticoagulant that may overcome many limitations seen with indirect thrombin inhibitors, such as heparin, by having a more predictable response, leaving the body more quickly, and avoiding conditions associated with the use of heparin such as thrombocytopenia.

Study subjects will be followed up for 12 months after the peripheral endovascular interventions .

Read More

This clinical trial is for men and women who will undergo coronary angiography,  a minimally invasive catheter-based procedure to visualize the arteries that supply blood to the heart, whose procedure is likely to include IVUS (intravascular ultrasound imaging, which employs a miniaturized ultrasound probe attached to the catheter).

The purpose of this study is to determine whether detecting cholesterol-rich plaques in the coronary arteries using near-infrared light can predict future coronary problems for persons who have already experienced such problems. Study subjects will be followed up for 2 years after the coronary angiography procedure.

Read More

This clinical trial is for men and women age 18 and older who have severe aortic valve stenosis and are scheduled to undergo a Transcatheter Aortic Valve Replacement procedure ("TAVR," also known as Transcatheter Aortic Valve Implantation or "TAVI").

The purpose of the study is to evaluate the safety and efficacy of the Sentinel™ Cerebral Protection System made by Claret Medical, Inc. The Sentinel system is intended to capture and remove blood clots that may form during a TAVR procedure so as to protect the brain from possible damage due to blockage of the arteries that supply blood to the brain.

Study subjects will be followed up for 90 days after the TAVR procedure.

Read More

Clinical Cardiology and Heart Failure

Enrollment in this trial is temporarily on hold.

This clinical trial is for men and women who are diagnosed with ischemic or congestive heart failure (CHF) after a myocardial infarction (MI or “heart attack”).  

The purpose of the study is to assess the efficacy and long-term safety of the CardioKinetix Parachute device, an umbrella-shaped membrane that is is implanted inside the left ventricle of the heart. This creates a partition in the ventricle, reducing the effective size of the chamber and restoring its natural shape somewhat, which has been shown to be important for the treatment of heart failure. It is implanted with a catheter procedure, avoiding the risks of surgery.

Study subjects will be followed up for 5 years after placement of the stent.

Read More

Enrollment in this study is temporarily on hold.

This clinical trial is for men and women moderate to severe heart failure (HF). The purpose of the study is to assess the safety and efficacy of the C-Pulse System, a device that is intended to relieve heart failure symptoms, improve quality of life and cardiac function, and reduce the need for heart failure hospitalization.

Unlike traditional heart assist devices, the C-Pulse system includes a small cuff around the aorta that inflates and deflates as the heart beats, increasing the heart’s oxygen supply and reducing the stress on the pumping chamber.  It is implanted outside the bloodstream, and maybe disconnected for personal hygiene.

Study subjects are follow up for five years after the device is implanted.

Read More

This clinical trial is for men and women who are being treated for with Pulmonary Hypertension (PH) or pulmonary arterial hypertension (PAH) but continue to experience symptoms such as  shortness of breath during exertion, dizziness, or fainting spells.

The purpose of this study is to evaluate the use of inhaled nitric oxide (iNO) with a pulsed delivery device (INOpulse DS). Similar treatments are approved only for conditions found in newborn babies.

There are two parts to this study. For the first 16 weeks, subjects are randomized to receive either one of  two doses of iNO delivered by a pulsed delivery device, or a placebo. All subjects who complete this part of the study are eligible to enter an extended study in which all subjects receive iNO. This part of the study continues until the entire study is closed.

Read More

Noninvasive Cardiac Imaging

This rearch study is for men and women who are admitted to the hospital for ST-elevated myocardial infarction (STEMI, or “heart attack”). The purpose of the study is to compare two forms of cardiac imaging—echocardiography or “echo,” and MRI—for the detection of blood clots (“thrombi”), which can cause stroke, and damage to heart’s papillary muscle, which can cause problems with the heart’s mitral valve and lead to the condition known as heart failure.

Read More

This rearch study is for men and women who are admitted to the hospital for ST-elevated myocardial infarction (STEMI, or “heart attack”). The purpose of the study is to test whether cardiac echocardiography (“echo”) can detect blood clots, or “thrombi,” more effectively in these patients if it is performed with the addition of perflutren lipid microspheres, a contrast agent that is approved by the Food and Drug Administration (FDA) to improve detection of thrombi with echo in selected populations.

Improving detection of thrombi may help physicians to predict the risk of STEMI patients for stroke.

Read More

Cardiology Services
for Researchers

Grants and Clinical Trials Central Administration:
(212) 746 2540

Electrophysiology Research:
(212) 746 4857

Interventional Cardiology Research:
(212) 746 4617

Heart Failure Research:
(212) 746 2698

Weill Cornell Connect Ways to Give Health Library

Weill Cornell Medical College
Division of Cardiology
520 East 70th Street
Starr 443
New York, NY 10021